Origin Life Panspermia

8 MCQs9-step worked example
Source: NCERT Structural Organisation in AnimalsPYQ coverage: NEET 2020, 2021, 2022, 2023, 2024, 2025Official key: NTA-verifiedLast reviewed: May 2026

Lesson

The high-frequency trap in origin-of-life questions: confusing what Miller-Urey actually synthesised (amino acids and simple organic molecules) with what Oparin-Haldane predicted as the precursor stage (coacervates / protobionts). NEET distractors exploit this gap — expect options listing nucleic acids or proteins as Miller-Urey products.

Oparin-Haldane hypothesis (chemical evolution). Life arose from inorganic molecules through a stepwise process on primitive Earth. The early atmosphere was reducing — rich in CH₄, NH₃, H₂, and H₂O vapour (no free O₂). Energy from UV radiation and lightning drove chemical reactions that formed simple organic molecules, which accumulated in warm water bodies ("primordial soup"). These monomers polymerised → complex organic molecules → self-assembling coacervates → primitive cells. Key point: this is abiogenesis — life from non-life (NCERT Class 12 Biology Chapter 6, page 126).

Miller-Urey experiment (1953). Stanley Miller and Harold Urey tested the Oparin-Haldane hypothesis experimentally. They sealed CH₄, NH₃, H₂, and H₂O in a closed apparatus, passed electric sparks (simulating lightning) for a week, and analysed the condensed products. Result: amino acids (glycine, alanine, aspartic acid), hydroxy acids, and other simple organic compounds formed abiotically. They did NOT produce DNA, RNA, proteins, or cells — only monomers.

Panspermia (cosmozoic hypothesis). An alternative proposal: life did not originate on Earth but arrived via meteorites or cosmic dust from elsewhere in the universe. This does not explain origin — it merely transfers the question to another location. NCERT mentions it as a contrast to chemical evolution.

Watch-out for NEET: Questions often pair panspermia with Oparin-Haldane as options to test whether you know panspermia is about transfer, not origin mechanism. Also watch for distractors that claim Miller-Urey synthesised proteins or nucleotides.


Practice MCQs

Select an option to see the explanation. Wrong answers show why your choice was tempting — and name the exact trap it exploits.

MCQ 1Easy RecallPractice

According to the Oparin-Haldane hypothesis, the primitive atmosphere of Earth was:

MCQ 2Easy RecallPractice

In the Miller-Urey experiment, which energy source was used to simulate natural conditions on primitive Earth?

MCQ 3Easy RecallPractice

The Miller-Urey experiment successfully produced:

MCQ 4Easy RecallPractice

The theory of panspermia proposes that:

MCQ 5Direct ApplicationPractice

Which gas was specifically ABSENT from the gas mixture used in the Miller-Urey experiment?

MCQ 6Concept TrapPractice

A student claims: "The Miller-Urey experiment proved that life can arise spontaneously from inorganic chemicals." Which statement best corrects this claim?

MCQ 7Direct ApplicationPractice

Which of the following correctly distinguishes the Oparin-Haldane hypothesis from the theory of panspermia?

MCQ 8Direct ApplicationPractice

Arrange the following events in the correct sequence according to the theory of chemical evolution:

Worked Example

  1. 1

    Given

    A NEET question states: "Which of the following was NOT a component of the gas mixture used by Miller and Urey in their experiment?" Options: (a) CH₄ (b) NH₃ (c) O₂ (d) H₂O vapour

  2. 2

    Required

    Identify the gas absent from the Miller-Urey apparatus.

  3. 3

    Concept

    The Miller-Urey experiment simulated a reducing atmosphere. Reducing means no free oxygen. The gas mixture was CH₄ + NH₃ + H₂ + H₂O (NCERT Class 12 Biology Chapter 6, page 126).

  4. 4

    Formula

    No mathematical formula applies — this is a factual recall question testing knowledge of experimental conditions.

  5. 5

    Substitution

    Check each option against the known gas list: - CH₄ ✓ (present) - NH₃ ✓ (present) - O₂ ✗ (deliberately excluded) - H₂O vapour ✓ (present)

  6. 6

    Calculation

    No calculation needed. Direct elimination confirms O₂ is the only option not in the apparatus.

  7. 7

    Final answer

    **(c) O₂** — free oxygen was absent because its oxidising nature would destroy nascent organic molecules.

  8. 8

    Common trap

    Students sometimes confuse H₂ (hydrogen gas, which WAS present) with O₂ (oxygen gas, which was NOT). The trap works because both are diatomic gases and students conflate "gases in the atmosphere" with "gases in Miller-Urey." Remember: reducing = no free O₂.

  9. 9

    Similar NEET-style question

    "In Miller's experiment, which of the following was used as a source of energy?" (a) Solar radiation (b) Electric discharge (c) Cosmic rays (d) Nuclear radiation Answer: (b) Electric discharge. ---

Before solving, remember these

Big Bang ~13.7 bya; Earth ~4.5 bya. Oparin-Haldane: chemical evolution from primordial soup. Miller-Urey (1953): CH4, NH3, H2, H2O + spark → amino acids. Panspermia: life from space.

-- NCERT Class 12 Biology, Ch. 6, p. 126

Formulas

Mendel's monohybrid ratio

F2 ratio in monohybrid cross — products of independent assortment of two alleles per locus.

SymbolQuantitySI Unit
ratioF2 progeny ratio-

Valid when

  • Single gene with complete dominance
  • Pure-bred parents

Mendel's dihybrid ratio

F2 ratio in dihybrid cross with two independently-segregating loci, complete dominance, no linkage.

SymbolQuantitySI Unit
ratioF2 phenotype ratio-

Valid when

  • Two unlinked loci
  • Complete dominance

Hardy-Weinberg equation

In an idealised population (no mutation, drift, selection, gene flow, random mating), allele and genotype frequencies remain constant.

SymbolQuantitySI Unit
pfreq of dominant allele A-
qfreq of recessive allele a-

Valid when

  • Idealised population
  • All five conditions met
  • Diploid, autosomal, biallelic locus

Recombination frequency (genetic mapping)

Proportion of recombinant offspring measures genetic distance between linked loci. Capped at 50% (independent assortment).

SymbolQuantitySI Unit
RFrecombination frequency%

Valid when

  • Linked loci on same chromosome

Exam Traps & Common Mistakes

These are the exact patterns that cause wrong answers in NEET. Each trap includes when it triggers and how to avoid it.

Category: Sign Convention

DNA polymerase synthesises only 5'→3'. Leading strand: continuous, same direction as fork. Lagging: discontinuous (Okazaki), opposite to fork.

When it triggers

Question on Okazaki, leading vs lagging, primer direction.

How to avoid

Reading template 3'→5'; synthesising 5'→3'. Lagging strand needs short fragments because it can't run continuously against fork direction.

Category: Negative Marking

Five forces disturb HW: mutation, gene flow, drift, selection, non-random mating. ANY of these violates equilibrium.

When it triggers

Question asks which factor maintains/disturbs HW.

How to avoid

Random mating + no other forces → equilibrium. ANY of mutation/migration/drift/selection/assortative mating → disequilibrium.

Category: Similar Terms

Monohybrid: genotype 1:2:1 (AA:Aa:aa); phenotype 3:1.

When it triggers

Question asks for one ratio while presenting cross details.

How to avoid

Always note dominance: phenotype merges Aa + AA; genotype keeps them separate.

Category: Similar Terms

X-linked recessive (haemophilia, colour-blindness): affects males predominantly; carrier mother → 50% sons affected; affected father → all daughters carriers but not affected.

When it triggers

Pedigree question; carrier vs affected.

How to avoid

Sex chromosomes: XX vs XY. Recessive on X needs both copies (XaXa) in female, only one (XaY) in male.

Category: Similar Terms

Allopatric: geographic isolation. Sympatric: same area, no physical barrier (e.g. polyploidy in plants, host-shift).

When it triggers

Question gives speciation scenario and asks which type.

How to avoid

If geographic barrier mentioned → allopatric. If population overlaps → sympatric.

Past Year Questions

51 questions from NEET 2020, 2021, 2022, 2023, 2024, 2025. Answers verified against NTA official keys.

NEET 2025

Identify the statement that is NOT correct.

1Constant region of heavy and light chains are located at C-terminus of antibody molecules
2Each antibody has two light and two heavy chains.
3The heavy and light chains are held together by disulfide bonds.
4Antigen binding site is located at C-terminal region of antibody molecules.
NTA Answer: Option 4(final)
NEET 2025

Given below are two statements : Statement I : In the RNA world, RNA is considered the first genetic material evolved to carry out essential life processes. RNA acts as a genetic material and also as a catalyst for some important biochemical reactions in living systems. Being reactive, RNA is unstable. Statement II : DNA evolved from RNA and is a more stable genetic material. Its double helical strands being complementary, resist changes by evolving repairing mechanism. In the light of the above statements, choose the most appropriate answer from the options given below :

1Statement I is incorrect but statement II is correct
2Both statement I and statement II are correct
3Both statement I and statement II are incorrect
4Statement I is correct but statement II is incorrect
NTA Answer: Option 2(final)
NEET 2024

Which one of the following can be explained on the basis of Mendel's Law of Dominance? A. Out of one pair of factors one is dominant and the other is recessive. B. Alleles do not show any expression and both the characters appear as such in F generation. 2 C. Factors occur in pairs in normal diploid plants. D. The discrete unit controlling a particular character is called factor. E. The expression of only one of the parental characters is found in a monohybrid cross. Choose the correct answer from the options given below:

1A, B and C only
2A, C, D and E only
3B, C and D only
4A, B, C, D and E
NTA Answer: Option 2(final)
NEET 2024

Which of the following statement is correct regarding the process of replication in E.coli?

1The DNA dependent DNA polymerase catalyses polymerization in one direction that is 3’ → 5’
2The DNA dependent RNA polymerase catalyses polymerization in one direction, that is 5’ → 3’
3The DNA dependent DNA polymerase catalyses polymerization in 5’ → 3’ as well as 3’ → 5’ direction
4The DNA dependent DNA polymerase catalyses polymerization in 5’ → 3’ direction
NTA Answer: Option 4(final)
NEET 2023

The phenomenon of pleiotropism refers to

1Presence of two alleles, each of the two genes controlling a single trait
2A single gene affecting multiple phenotypic expression
3More than two genes affecting a single character
4Presence of several alleles of a single gene controlling a single crossover
NTA Answer: Option 2(final)
NEET 2023

Expressed Sequence Tags (ESTs) refers to

1All genes that are expressed as proteins.
2All genes whether expressed or unexpressed.
3Certain important expressed genes.
4All genes that are expressed as RNA.
NTA Answer: Option 4(final)
NEET 2023

Which of the following statements are correct about Klinefelter’s Syndrome? A. This disorder was first described by Langdon Down (1866). B. Such an individual has overall masculine development. However, the feminine developement is also expressed. C. The affected individual is short statured. D. Physical, psychomotor and mental development is retarded. E. Such individuals are sterile. Choose the correct answer from the options given below:

1C and D only
2B and E only
3A and E only
4A and B only
NTA Answer: Option 2(final)
NEET 2022

Given below are two statements : Statement I : Mendel studied seven pairs of contrasting traits in pea plants and proposed the Laws of Inheritance. Statement II : Seven characters examined by Mendel in his experiment on pea plants were seed shape and colour, flower colour, pod shape and colour, flower position and stem height. In the light of the above statements, choose the correct answer from the options given below :

1Statement I is incorrect but Statement II is correct
2Both Statement I and Statement II are correct
3Both Statement I and Statement II are incorrect
4Statement I is correct but Statement II is incorrect
NTA Answer: Option 2(final)
NEET 2022

Statements related to human Insulin are given below. Which statement(s) is/are correct about genetically engineered Insulin? (a) Pro-hormone insulin contain extra stretch of C-peptide (b) A-peptide and B-peptide chains of insulin were produced separately in E.coli, extracted and combined by creating disulphide bond between them. (c) Insulin used for treating Diabetes was extracted from Cattles and Pigs. (d) Pro-hormone Insulin needs to be processed for converting into a mature and functional hormone. (e) Some patients develop allergic reactions to the foreign insulin. Choose the most appropria

1(c), (d) and (e) only
2(a), (b) and (d) only
3(b) only
4(c) and (d) only
NTA Answer: Option 3(final)
NEET 2021

Match List-I with List-II. (2) (a)-Replication; (b)-Transcription; (c)-Transduction; (d)-Protein (3) (a)-Translation; (b)-Replication; (c)-Transcription;(d)-Transduction (4) (a)-Replication; (b)-Transcription; (c)-Translation; (d)-Protein Answer (4) Choose the correct answer from the options given 127. Which of the following are not secondary below. metabolites in plants? (a) (b) (c) (d)

1Rubber, gums (1) (ii) (i) (iv) (iii)
2Morphine, codeine (2) (ii) (iv) (i) (iii)
3Amino acids, glucose (3) (iv) (iii) (ii) (i)
4(iii) (i) (iv) (ii) (4) Vinblastin, curcumin
NTA Answer: Option 2(final)
NEET 2020

Which of the following refer to correct example(s) of organisms which have evolved due to changes 97. ÁŸêŸ ◊ ∑§ÊÒŸ, ∞ ‚ ¡ËflÊ ∑ § ‚„Ë ©ŒÊ„⁄UáÊÊ ∑§Ê ‚ ŒÁ÷¸Ã ∑§⁄UÃÊ „Ò in environment brought about by anthropogenic ¡Ê ◊ÊŸfl ∑§Ë Á∑˝§ÿÊ•Ê mÊ⁄UÊ flÊÃÊfl⁄UáÊ ◊ ’Œ‹Êfl ∑ § ∑§Ê⁄UáÊ action ? Áfl∑§Á‚à „È∞ „Ò? (a) Darwin’s Finches of Galapagos islands. (a) ªÒ‹Ê¬ÒªÊ mˬ ◊ «UÊÁfl¸Ÿ ∑§Ë Á» §ø (b) Herbicide resistant weeds. (b) π⁄U¬ÃflÊ⁄UÊ ◊ ‡ÊÊ∑§ŸÊ‡ÊË ∑§Ê ¬˝ÁÃ⁄UÊ œ (c) Drug resistant eukaryotes. (c) ‚‚Ë◊∑ §ãŒ˝∑§Ê ◊ ŒflÊßÿÊ ∑§Ê ¬˝ÁÃ⁄UÊ œ (d) Man-created breeds of domesticated animal

1∑ §fl‹ (d) (1) only (d)
2∑ §fl‹ (a) (2) only (a)
3(a) ∞fl (c) (3) (a) and (c)
4(b), (c) ∞fl (d) (4) (b), (c) and (d) Hindi+English 23 H3
NTA Answer: Option 4(final)
NEET 2020

•ŸÈ‹ πŸ ∑ § ‚◊ÿ «UË.∞Ÿ.∞. ∑§Ë ∑È §«U‹Ë ∑§Ê πÊ ‹Ÿ ◊ ∑§ÊÒŸ‚Ê

1RNA polymerase ∞ ¡Êß◊ ◊ŒŒ ∑§⁄UÃÊ „Ò?
2DNA ligase (1) •Ê⁄U.∞Ÿ.∞. ¬ÊÚÁ‹◊⁄ U$¡
3DNA helicase
4DNA polymerase (2) «UË.∞Ÿ.∞. ‹Êߪ $¡ (3) «UË.∞Ÿ.∞. „Ò‹Ë∑ §$¡ 117. Snow-blindness in Antarctic region is due to : (4) «UË.∞Ÿ.∞. ¬ÊÚ‹Ë◊⁄ U$¡ (1) Damage to retina caused by infra-red rays (2) Freezing of fluids in the eye by low
NTA Answer: Option 1(final)
NEET 2020

¡ËŸ ‘I’ ¡Ê ABO ⁄UÄà flª¸ ∑§Ê ÁŸÿ òÊáÊ ∑§⁄UÃÊ „Ò ©‚∑ § ‚ Œ÷¸ 121. Identify the wrong statement with reference to the gene ‘I’ that controls ABO blood groups. ◊ ª‹Ã ∑§ÕŸ ∑§Ê ¬„øÊÁŸ∞–

1Allele ‘i’ does not produce any sugar. (1) ‘i’ ∞ ‹Ë‹ ∑§Ê ߸ ÷Ë ‡Ê∑¸§⁄UÊ ©à¬ÛÊ Ÿ„Ë ∑§⁄UÃÊ–
2The gene (I) has three alleles. (2) ¡ËŸ (I) ∑ § ÃËŸ ∞ ‹Ë‹ „Ê Ã „Ò –
3A person will have only two of the three (3) ∞∑§ √ÿÁÄà ◊ ÃËŸ ◊ ‚ ∑ §fl‹ ŒÊ ∞ ‹Ë‹ „Ê ª – alleles.
4¡’ IA ∞fl IB ŒÊ ŸÊ ß∑§_ „Ê Ã „Ò , ÿ ∞∑§ ¬˝∑§Ê⁄U ∑§Ë (4) When IA and IB are present together, they ‡Ê∑¸§⁄UÊ •Á÷√ÿÄà ∑§⁄Uà „Ò – express same type of sugar.
NTA Answer: Option 4(final)
NEET 2020

≈˛UÊ ‚‹ ‡ÊŸ (•ŸÈflÊŒŸ/SÕÊŸÊ Ã⁄UáÊ) ∑§Ë ¬˝Õ◊ •flSÕÊ ∑§ÊÒŸ ‚Ë 123. The first phase of translation is : „Ê ÃË „Ò?

1Recognition of an anti-codon (1) ∞∑§ ∞ ≈UË-∑§Ê «UÊÚŸ ∑§Ë ¬„øÊŸ
2Binding of mRNA to ribosome (2) ⁄UÊß’Ê ‚Ê ◊ ‚ mRNA ∑§Ê ’㜟
3Recognition of DNA molecule (3) «UË.∞Ÿ.∞. •áÊÈ ∑§Ë ¬„øÊŸ
4Aminoacylation of tRNA (4) tRNA ∑§Ê ∞ ◊ËŸÊ ∞‚Ë‹ ‡ÊŸ
NTA Answer: Option 4(final)
NEET 2020

◊ «U‹ Ÿ Sflà òÊ M§¬ ‚ ¬˝¡ŸŸ ∑§⁄UŸ flÊ‹Ë ◊≈U⁄U ∑ § ¬ÊÒœ ∑§Ë 130. How many true breeding pea plant varieties did Mendel select as pairs, which were similar except Á∑§ÃŸË Á∑§S◊Ê ∑§Ê ÿÈÇ◊Ê ∑ § M§¬ ◊ øÈŸÊ ¡Ê Áfl¬⁄UËà Áfl‡Ê ∑§Ê in one character with contrasting traits ? flÊ‹ ∞∑§ ‹ˇÊáÊ ∑ § •‹ÊflÊ ∞∑§ ‚◊ÊŸ ÕË?

18 (1) 8
24 (2) 4
32 (3) 2
414 (4) 14 H3 30 Hindi+English
NTA Answer: Option 4(final)

How NEET usually asks this

Recurring question shapes from past papers. Each pattern shows why wrong options look tempting.

Sources

NCERT refs: Class 12 Biology Chapter 6, p.126

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